A-209 Cognitive Effects of Sickle Cell Disease in Children

Abstract Objective: Multiple contributors to neurocognitive impairment in individuals with sickle cell disease (SCD) have been identified. Research indicates that a history of cerebrovascular accidents are associated greater cognitive decline among children disease, specifically visual-spatial tasks. Studies also indicated the presence age effects within this population. The purpose research is examine specific domains impacted by severity and age. Method: Archival data from National Institutes Health’s Cooperative Study Sickle Cell Disease was used. Data restricted aged 14 or younger (N= 2,408), 47.8% (n = 1,152) female 52.2% 1,256) male. Black African American (96.9%, n 2,334) made up majority sample, remainder coded as “other” (2.8%, 68). measures utilized included Wechsler Intelligence Scale for Children-Revised (WISC-R), Children-Third Edition (WISC-III), Woodcock Johnson-Revised (WJ-R), Peabody Picture Vocabulary Test (PPVT). Results: negatively correlated some aspects functioning, domain [F(2, 1) 4.42, p .013, η² .02]. Age inversely perceptual organization (r -.36, .02) visual motor abilities -.49, .001). Conclusions: Results revealed several functioning. Cognitive increased Introducing remediation interventions at earlier stages may help reduce significant deficits.